CONCLUSIONS: In stable coronary artery disease, intravascular imaging-verified beneficial changes in plaque morphology after evolocumab treatment were associated with restored mitochondrial function, suppressed inflammation, and alleviated oxidative stress. Similar studies of plaque morphology with noninvasive modalities would allow the confirmation of novel pathways of plaque stabilization in response to maximized lipid-lowering therapy in larger number of subjects.

CONCLUSIONS: Systemic reforms including decreased mandatory overtime, staffing, workload distribution, organizational support, training, improved communication, access to adequate resources and psychosocial interventions may help promote wellness and optimize the ability of healthcare workers to provide care in forensic-correctional settings. However, the preliminary nature of the study findings suggests caution in their interpretations. Further high-quality research is needed to support...

No abstract

Turtle acanthocephalans are a depauperate group of helminths, yet they parasitize a quarter of all turtle species in North America. Despite acanthocephalans being common in turtles, their potential as disease-causing agents remains unknown. In other vertebrate hosts, acanthocephalans are known to cause pathologic changes upon attachment (via with their armed proboscis) to the intestinal wall of the host. Herein, we report new turtle host associations, ultrastructural characterization, and...

The antigen presenting molecule MHC class I-related protein 1 (MR1) binds small molecule metabolites derived from the microbial riboflavin biosynthetic pathway and presents them at the cell surface for surveillance by MR1-restricted mucosal-associated invariant T cells (MAIT cells). MR1 ligands can originate in the extracellular space or in endosomal compartments that contain microbial pathogens. Distinct, complementary antigen processing and presentation pathways enable MR1 to survey diverse...