OBJECTIVE: As therapeutic options are rapidly expanding to treat pain of discogenic and vertebrogenic origin, it is important for the clinician to have an evidence-based understanding of the latest information regarding the normal and pathological anatomy of the intervertebral disc as well as imaging characteristics and treatment strategies. The American Society of Pain and Neuroscience (ASPN) commissioned the DISC project to inform and update the interventional spine community about anterior...

CONCLUSIONS: Compared to reported UTIs rates from 2000 to 2002 of 17 %, our findings show that the occurrence of UTIs during pregnancy has decreased to 13 %. Given the relevant significant findings, increased screening for depression and IPV may be warranted for those presenting with UTI. In addition, increased screening for UTIs in Black, American Indian, and multiracial women can help prevent the development of serious sequelae of pregnancy-associated UTIs.

CONCLUSION: The highly increased risks for primary and secondary neoplasms and mortality warrant close clinical surveillance of individuals with NF1.

CONCLUSIONS: This study identifies HER2 IHC discordance and specific genomic and immune features as prognostic biomarkers of T-DXd efficacy. These findings warrant prospective validation and may inform biomarker-driven strategies to optimize T-DXd therapy in HER2-expressing malignancies.

A search for the dimuon decay of the Higgs boson is presented based on pp collision data recorded by ATLAS during Run 3 of the Large Hadron Collider, corresponding to an integrated luminosity of 165 fb^{-1} at sqrt[s]=13.6 TeV. To enhance the sensitivity, the results are combined with those from Run 2. An excess of events over the background is observed with a significance of 3.4σ (2.5σ expected). The best-fit signal strength is μ=1.4±0.4. This result provides evidence for the H→μμ decay with...