CONCLUSIONS: Cisplatin combined with elimusertib was associated with hematologic toxicity requiring significant dose de-escalation. Elimusertib PK was consistent with prior studies. Only modest activity was observed. Further clinical evaluation of elimusertib plus cisplatin is not warranted.

This work outlines a process for producing high-purity (>95%) carboxylate surfactants from post-consumer recycled high-density polyethylene (PCR-HDPE). The approach involves the thermal depolymerization of PCR-HDPE via pyrolysis, followed by fractional distillation to isolate C9-C14 olefins. These olefins undergo hydroformylation using cobalt carbonyl catalysts to generate aldehydes, which are subsequently oxidized to carboxylic acids using Pinnick oxidation under mild aqueous-phase conditions....

Topological textures exemplify matter and energy configuration governed by inherent physical laws. Recently skyrmion-like textures possessing fixed topology have been realized in diverse optical systems, ranging from evanescent fields, structured media to free space. Magnetic skyrmions, with their tunable topological features via external stimuli, hold promise for innovative devices, such as memory, logic gates, and neuromorphic computing. However, achieving dynamic control over non-trivial...

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