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the Gateway to Research in Oklahoma

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Gateway to Research in Oklahoma


Oklahoma Shared Clinical and Translational Resources U54 GM104938

Researchers

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The GRO: Researcher Portal provides resources, information, and training to help individuals or communities involved in performing clinical and translational research in Oklahoma.

Providers

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The GRO: Provider Portal assists medical providers to identify clinical research opportunities in Oklahoma, tools for patient education, and evidence-based resources to improve patient care.

Patients

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The GRO: Patient Portal can help patients and families to learn more about clinical and translational research and to connect with opportunities to participate in research opportunities in your communities.

Oklahoma Research Highlights

Anti-SARS-CoV-2 Small Molecule Targeting of Oxysterol-Binding Protein (OSBP) Activates Cellular Antiviral Innate Immunity

3 months ago
Human oxysterol-binding protein (OSBP) is a potentially druggable mediator in the replication of a broad spectrum of positive-sense (+) single-stranded RNA (ssRNA) viruses, including members of the Picornaviridae, Flaviviridae, and Coronaviridae. OSBP is a cytoplasmic lipid transporting protein capable of moving cholesterol and phosphoinositides between the endoplasmic reticulum (ER) and Golgi, and the ER and lysosome. Several structurally diverse antiviral compounds have been reported to...
Bharathiraja Subramaniyan

The relationship of lactating beef cow metabolizable energy intake to energy partitioning, milk composition, and calf performance

3 months ago
A two-year experiment was conducted to determine the impact of maternal metabolizable energy intake (MEI) on energy partitioning and performance of beef cows and calves. Forty mature crossbred Angus beef cows (6 ± 2.0 y, 534 ± 60 kg BW) were used each year along with their suckling steer calves (84 ± 8.7 d, 130 ± 15 kg BW). Cows were stratified by early-lactation milk yield and randomly assigned to 1 of 5 levels of metabolizable energy intake. Each treatment group was housed in a dry lot pen....
Courtney M Williams

Treatment of antibiotic-manufacturing wastewater enriches for Aeromonas veronii, a zoonotic antibiotic-resistant emerging pathogen

3 months ago
Antibiotic-manufacturing wastewater treatment plants primarily target chemical pollutants, but their processes may select for antibiotic-resistant pathogens and antibiotic resistance genes. Here, leveraging the combined strengths of deep metagenomic sequencing, 16S rRNA gene sequencing, qPCR, and bacterial culturing, we investigated bacterial communities and antibiotic resistomes across eleven treatment units in a full-scale antibiotic-manufacturing wastewater treatment plant processing...
Xingshuo Wang

Inhibition of CYP450 pathways reduces Functional Sympatholysis in healthy young adults

3 months ago
Functional sympatholysis, the blunting of sympathetic vasoconstriction during exercise, is critical for regulating exercise hyperemia. The role of cytochrome P450-2C9 (CYP450) pathways in functional sympatholysis remain unclear. 21 participants (11 females) completed three study visits (2 experimental). Participants ingested a placebo (PLA) or CYP450 inhibitor fluconazole (FLZ) 120 minutes before testing in a double-blind, randomized, crossover design. Forearm blood flow (FBF) and mean arterial...
Alexander A Buelow

Fe(OTf)3 or Photosensitizer-free blue light activated diazo-thioglycoside donors for Iterative and stereoselective glycosylations

3 months ago
Conventional methods for thioglycoside activation often rely on precious and toxic platinum group metals. Here, we report a catalytic glycosylation strategy employing diazo-thioglycoside donors activated by earth-abundant iron or photosensitizer-free blue light conditions. It confers orthogonal reactivity relative to most glycosyl donors, including widely used thioglycosides and alkyne-based donors, thereby enabling one-pot orthogonal synthesis of glycans. The Thorpe-Ingold-like effect drives...
Surya Pratap Singh

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