The sigma-2 receptor (σ(2)R/TMEM97) is a clinically relevant membrane protein involved in cholesterol regulation and overexpressed in cancer and neurodegenerative diseases. Despite its therapeutic potential, the dynamic mechanisms underlying σ(2)R function and ligand binding remain poorly understood. Here, we combined adaptive sampling molecular dynamics simulations with quasi-anharmonic analysis and unsupervised machine learning method to investigate the conformational behavior of the σ(2)R...

A Fe(III) porphyrin(2.1.2.1) oxo-bridged dimer complex was synthesized using porphyrin(2.1.2.1) as a bent ligand. The resulting complex adopts an oxo-bridged and cross-stacked molecular structure. DFT calculations reveal antiferromagnetic coupling between the two iron centers, characterized by an exchange coupling constant of J = -129.5 cm^(-1). TDDFT simulations reproduce the key features of the experimental UV-vis spectrum, indicating that the brightest transitions correspond to a...

CONCLUSION: This study found significant sex-based differences in the in-hospital outcomes of PE thrombectomy. Female patients had higher rates of peri-procedural bleeding and lower rates of AKI, but no sex differences were observed in mortality after adjusting for confounders. Further studies are needed to explore the underlying mechanisms of these disparities and improve patients care.

CONCLUSIONS: GB with CT was well-tolerated with 1 DLT noted. The study was prematurely stopped when the development of GB was discontinued, but targeting TGFb downstream signaling remains of interest.

CONCLUSION: This is the first bibliometric analysis of novel cell death in the context of IBD. It offers a holistic overview of research dynamics, trends, and hotspots in this field, which can enhance the comprehension of the field modalities and offer valuable guidance for future research. Future studies should focus on the interactions between different cell death forms and accelerate the translation of basic research findings into clinical applications.