Micromobility offers a potential pathway to strengthen urban disaster resilience by enabling the distribution of emergency supplies when infrastructure or transportation networks are compromised. This study examines the viability of micromobility vehicles for post-disaster relief via agent-based modeling and simulations in Stillwater, Oklahoma. Focusing on the early recovery phase with exclusive micromobility deployment, three operational variables are evaluated: deployment rate, load capacity,...

CRISPR-Cas12a, an RNA-based DNA targeting system, is widely used for genome editing and biomarker detection. To mitigate the off-target DNA cleavage of Cas12a, we previously developed a Francisella novicida Cas12a variant (FnoCas12a^(KD2P)) by introducing double proline substitutions (K969P/D970P) in a conserved arginine-rich helix called the bridge helix (BH). In this work, we use a combinatorial approach to understand the molecular mechanisms of BH-mediated activation of Cas12a for DNA...

Biaryl motifs are central in pharmaceutical drug design, yet conventional synthesis via palladium-catalyzed cross-coupling poses increasing sustainability and cost concerns. The study presented herein explores a greener alternative to palladium using iron(II) complexes supported by tetra-aza macrocyclic ligands for direct arylation of pyrrole with phenylboronic acids. Under aerobic conditions, the optimized [Fe^(2+)L1(Cl)(2)] complex of ligand Me(2)Cyclam (L1;...

CONCLUSION: STEMI incidence, mortality, and MCS utilization among young adults have increased between 2004 and 2023, with a steeper uptrend observed post-COVID. Further research is needed to identify effective prevention and treatment strategies for STEMI in young adults, particularly in the post-COVID era.

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