CONCLUSIONS: Multimodal, opioid-sparing regimens that incorporate both pharmacologic and non-pharmacologic agents offer the most balanced approach to pain management after TJA. While promising, wider implementation is limited by cost, access, and a paucity of arthroplasty-specific trials. Future directions include integration of artificial intelligence to individualize regimens, use of predictive pain algorithms, and real-time physiologic pain monitoring. Broader clinical validation and economic...

CONCLUSION: IC events induced bias toward the null in the estimated association between HCQ taper/cessation and lupus flares. Data-driven simulations are useful for quantitative bias analyses in complex situations, as they allow accounting for relevant characteristics of a particular real-world dataset.

No abstract

CONCLUSION: Race and ethnicity poorly predict symptoms of depression, particularly when using standard OMB categories (i.e., ethnically-stratified, mono-racial). Models allowing for overlapping racial and ethnic identities outperformed those using mutually-exclusive categorizations. Results suggest that health equity research should account for racial and ethnic heterogeneity and consider SES in addressing racial and ethnic differences in mental health among young adults at the population level.

Pulsed laser deposition (PLD) is a well-established method for synthesizing thin films, enabling precise control over growth parameters while maintaining stoichiometry across the specimen. Integrating PLD with combinatorial studies offers a significant advantage for conducting high-throughput experiments, thereby accelerating discovery. In this work, we introduce a reliable and reproducible approach for combinatorial thin-film synthesis that features spatially controlled thickness gradients on a...