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Gateway to Research in Oklahoma


Oklahoma Shared Clinical and Translational Resources U54 GM104938

Researchers

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The GRO: Researcher Portal provides resources, information, and training to help individuals or communities involved in performing clinical and translational research in Oklahoma.

Providers

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The GRO: Provider Portal assists medical providers to identify clinical research opportunities in Oklahoma, tools for patient education, and evidence-based resources to improve patient care.

Patients

imgPatients

The GRO: Patient Portal can help patients and families to learn more about clinical and translational research and to connect with opportunities to participate in research opportunities in your communities.

Oklahoma Research Highlights

Environmental stress shapes persistence-like phenotypes and genomic changes in <em>Escherichia coli</em> and <em>Morganella morganii:</em> an exploratory study

2 months 2 weeks ago
INTRODUCTION: Enterobacterales, including E. coli and M. morganii, employ adaptive mechanisms to withstand environmental and host-related stressors, including extreme temperatures, osmotic pressure changes, acidic conditions, and antibiotic pressures. Survival in these conditions can consequently enhance their antibiotic tolerance and persistence. Bacterial persistence contributes to chronic infections and antibiotic treatment failure. This exploratory study investigates the impact of stress...
Tosin Yetunde Senbadejo

A vision transformer-radiomics approach for enhanced chemotherapy outcome prediction in ovarian cancer

2 months 2 weeks ago
CONCLUSION: These findings demonstrate that integrating complementary imaging representations enhances chemotherapy response prediction. The combination of transformer-based embeddings and radiomics features provides rich, task-specific tumor characterization from CT imaging and supports the development of precision oncology decision tools.
Neman Abdoli

Refractive Outcomes of Cataract Surgery Using Zeiss Artificial Intelligence Calculator versus Barrett Universal II and Kane

2 months 2 weeks ago
CONCLUSION: Compared to BU2, ZAIC produces a lower MAE, SD, and RMSAE, and a higher proportion of eyes within 0.5 and 0.75 D of predicted but performs similarly to Kane across all outcome measures. This remains true regardless of whether K or TK is used as an input. This study is limited by its retrospective design and use of a single MX60E IOL model.
Nathan T Cannon

Large-Scale Evaluation of Traditional Chinese Medicines Reveals Potential PPARγ Modulators for Type 2 Diabetes Management

2 months 2 weeks ago
CONCLUSIONS: This study identified 45 novel TCM candidates for T2D management. While several TCMs demonstrated PPARγ inhibition despite their traditional use for diabetic symptom alleviation, our findings suggest that a comprehensive evaluation is essential to balance their immediate clinical benefits with long-term metabolic management and potential side effects.
Mingyuan Dou

miR-484 sensitizes in IDH-wild and IDH-mutant glioblastoma cells to temozolomide by inhibiting oncogenic FOXM1 signaling

2 months 2 weeks ago
No abstract
Nursultan Nurdinov

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