Accurate precipitation forecasting is becoming increasingly important in the context of climate change. In response, machine learning-based approaches have recently gained attention as an emerging alternative to traditional methods such as numerical weather prediction and climate models. Nonetheless, many recent approaches still rely on off-the-shelf loss functions, and even the more advanced ones merely involve optimization processes based on the critical success index (CSI). The problem,...

BACKGROUND: Cannabis-related concerns include young adult use and sociodemographic disparities. We examined sociodemographic subgroup perceptions of targeted cannabis-related law enforcement and marketing.

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CONCLUSIONS: Our work identified hormonal contraception use in less than one-third of reproductive-age females with sickle cell disease using employer-sponsored insurance. Over 40% of new users of hormonal contraception received prescriptions for estrogen-containing agents, demonstrating a need for education regarding the 2024 U.S. MEC recommendations, which contradict estrogen for patients with sickle cell disease. Future directions should also include understanding patient characteristics and...

Airway remodeling in asthma is characterized by increased extracellular matrix (ECM) production and deposition by airway smooth muscle (ASM) cells. Existing studies have shown contrasting effects of 17β-estradiol (E(2)) in regulating ASM cellular remodeling via differential activation of estrogen receptors (ERs: α and β). Even though downstream metabolites of E(2) (2-hydroxyestradiol: 2-HE and 16-hydroxyestradiol: 16αHE(2)) are gaining recognition for their biological roles in various cellular...