CONCLUSIONS: These findings demonstrate systemic dissemination of tumor-derived sEVs during DCIS progression, suggesting roles in early microenvironmental conditioning and metastatic preconditioning prior to overt invasion.

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The current study engages precarious masculinity as a framework to examine sexual health in magazines marketed for male audiences. Precarious masculinity is the idea that masculinity is fragile and always being challenged or questioned, particularly considering pressures to defend the social status and privilege associated with masculinity. We conducted a qualitative content analysis of the text or "coverlines" on the covers of Men's Health magazines over nearly 40 years (1986-2024; N = 333) of...

CONCLUSIONS: PIC improved the growth performance and health status of weaned piglets through the regulation of Nrf2-mediated redox homeostasis and modulation of the related gut microbiota, offering a potential new natural antioxidants for mitigating weaning stress in piglets.

Exercise is a potent modulator of mental health, with accumulating evidence highlighting its ability to produce structural and functional changes in the brain. This review synthesizes findings across neurobiological, molecular, and systemic domains to explain how exercise improves outcomes in mood, anxiety, and stress-related disorders. We examine how exercise stimulates brain-derived neurotrophic factor (BDNF), regulates monoaminergic systems (serotonin, dopamine, norepinephrine), modulates...