Acquired hemophilia A (AHA) is a rare autoimmune disorder caused by autoantibodies against factor VIII, leading to severe bleeding. According to the European Acquired Hemophilia (EACH2) registry, AHA has an incidence of approximately 1.5 cases per million per year, most often presenting in the elderly population. This case report highlights the diagnostic challenges and multidisciplinary management of a high-titer inhibitor in an elderly male with delayed presentation. A 65-year-old male...

CONCLUSION: Tirzepatide-based combination therapy was associated with clinically meaningful weight loss and comorbidity improvement in adults with HO. These cases support further study of targeted, multimodal regimens in patients with acquired HO.

CONCLUSION: High-dose AT with heparin mitigates andexanet-induced heparin resistance in vitro, though residual TG and clot formation suggest ongoing thrombotic risk, warranting further study.

Promoting sustainable development worldwide requires collaborative efforts across interconnected systems under integrated frameworks. Here, we illustrate the integrated metacoupling framework as a holistic lens for analyzing human-nature interactions within and between systems to advance integrated sustainability analysis. We propose six interrelated steps to operationalize the framework for Sustainable Development Goals' interaction analysis, progress assessment, and pathway modeling,...

BACKGROUND: Ecchordosis physaliphora (EP) is a rare notochordal remnant and the benign counterpart to chordomas with the same cell of origin. They are most commonly located intracranially along the posterior clivus in the prepontine cistern. EPs are typically discovered incidentally, but a small subset can present with symptoms, including a CSF leak. There are very few reported cases of EP-related meningitis, which occur after a short course of CSF leakage.