Tyrosine nitration alters the structure, function, and cellular localization of proteins and is implicated in the pathology of multiple diseases [G. Ferrer-Sueta et al., Chem. Rev. 118, 1338-1408 (2018), H. Ischiropoulos, Arch. Biochem. Biophys. 356, 1-11 (1998), I. Griswold-Prenner et al., J. Biol. Chem. 299, 105038-10554 (2023)]. Although protein nitration is assumed to proceed via nonspecific chemical mechanisms, it is highly selective, suggesting the possibility of enzymatic catalysis. Here,...

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Chagas disease is an infectious disease caused by the parasite Trypanosoma cruzi, with heart failure being a severe complication of its chronic stage. T. cruzi has three lifecycle stages: epimastigote, trypomastigote, and amastigote. Amastigotes are the intracellular form that invade mammalian host cells, replicate in their cytoplasm, and cause tissue damage. Due to the small size of T. cruzi amastigotes, fine spatial resolution would be beneficial. Current metabolomics research on Chagas...

Volatile organic compounds (VOCs) are common sources of occupational exposure throughout a variety of industries. To protect personnel from overexposure, field industrial hygienists must conduct compliance sampling. In efforts to improve upon analytical sensitivity and time-to-knowledge of existing VOC exposure assessment methods, the industrial hygiene research group at UAB has developed a preanalytical technique known as photothermal desorption (PTD), which uses pulses of high-energy light to...

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