Diffuse hemispheric glioma, H3 G34-mutant (DHG-H3 G34) has been primarily molecularly characterized by methylation profiling and sequencing studies. We describe an integrated histomolecular evaluation including high-resolution copy number profiling of a series of 60 DHG-H3 G34 to further our understanding of the spectrum of genetic changes associated with this tumor type. Cases were clinically tested using an 187-gene mutation and fusion targeted neuro-oncology next-generation sequencing panel...

We detected Borrelia puertoricensis in migratory Mexican free-tailed bats sampled in Oklahoma during 2022 and 2023, representing only the second detection of this relapsing fever species in wild vertebrates. Although prevalence was low (0.79%), our findings suggest migratory bats could contribute to dispersal of tick-borne pathogens in North America.

Accurately identifying microplastics (MPs) poses a challenge because environmental and human activities, like thermal oxidation (common in wildfires, urban fires, and waste burning) and mechanical abrasion (common in riverine and marine environments), chemically modify the plastic structure. Conventional Fourier transform infrared (FTIR) libraries lack the accuracy to identify these plastics because degradation alters their spectra-thermal oxidation adds new peaks, and abrasion causes...

Tumor-associated antigen (TAA) vaccines are being explored as a strategy to induce antitumor immune responses. Mammaglobin-A (Mam-A) is a TAA expressed in >50% of breast cancer (BC) patients. Previously, we have shown that Mam-A DNA vaccines induce antitumor immune responses in patients with stable metastatic disease. To further evaluate the potential of the Mam-A vaccine, we initiated a phase-1b clinical trial in estrogen receptor-positive BC patients prior to surgery. Eight patients were...

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