Microplastic pollution fosters the development of distinct microbial biofilm communities, termed the plastisphere, that vary across environmental contexts. Here, we used 16S rRNA gene sequencing combined with machine learning (ML) approaches to explore plastisphere microbial diversity and the interactions between potential plastic-degrading bacteria (PDBs) and non-plastic-degrading bacteria (NDBs) across ocean, surface water, and wastewater habitats. Our findings reveal that wastewater...

The gut microbiome is vital in maintaining overall health, yet its complexity and dynamic interactions are still not fully understood. This diverse microbial community comprises bacteria, viruses, fungi, and archaea, contributing to metabolism, immune regulation, and disease susceptibility. However, imbalances in the gut microbiome (dysbiosis), have been linked to various diseases, underscoring the importance of understanding microbial interactions within the gut ecosystem. This review explores...

Echinococcoses are neglected zoonotic diseases caused by larval cestodes of the genus Echinococcus. Regions of the United States rarely experience locally acquired infections, and most contemporary cases are presumed to be imported, predominantly from hyperendemic regions such as Central and East Asia, the Middle East, and North Africa. However, significant knowledge gaps remain regarding the current disease burden within the US healthcare system. The epidemiology, baseline clinical features,...

The Phase 1/2 Intergroup study E4412 (NCT01896999; ClinicalTrials.gov) investigated checkpoint blockade with nivolumab (Nivo) and ipilimumab (Ipi) in relapsed/refractory (R/R) classic Hodgkin lymphoma (HL) while concurrently targeting CD30+ Hodgkin Reed Sternberg cells with the antibody-drug conjugate brentuximab vedotin (BV). 147 patients ≥12 years were randomized between BV/Nivo and BV/Ipi/Nivo; 132 patients are included in primary efficacy analysis. The primary endpoint, complete response...

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