Predicting clinical therapeutic outcomes from animal studies using conserved electrophysiological phenotypes could facilitate developing treatments for neuropsychiatric disorders. Alpha oscillations in human resting-state electroencephalogram recordings are altered in many disorders, but whether these disruptions exist in mouse models is unknown. Here, we employed a uniform analytical method to show in males with fragile X syndrome (FXS) that alpha oscillations in humans and alpha-like...

Autologous stem cell transplant (ASCT) and chimeric antigen receptor T cell therapy (CAR T) are approved treatments both with curative potential and/or excellent response rates in patients with aggressive hematologic malignancies. However, multiple barriers hinder the delivery of these treatments and thereby affecting access to patients. Minority patients are less likely to receive ASCT, and when they do, outcomes may not match those of non-minority patients, highlighting the need for...

Drusen and subretinal drusenoid deposits, the pathognomonic lesions for age-related macular degeneration (AMD), are rich in cholesterol. Yet, AMD is not consistently linked to plasma lipids. Here wild-type and human apolipoprotein B100-expressing (APOB100) mice were put on a Western type of diet for 13 months and then assessed for plasma lipid profile, high-density lipoprotein (HDL) heterogeneity, status of intraretinal and choroidal vasculatures, retinal structure, function, levels of...

CONCLUSION: Asking older adults about their acute stress responses to ageism is a promising strategy in research investigating mechanisms implicating ageism in poor health outcomes. In clinical practice, this may increase self-awareness and adoption of healthy strategies to manage ageism-related responses and coping.

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