CONCLUSIONS: This HAC may be useful for minimizing perianesthetic hypothermia in rabbits.

CONCLUSION: Reliable radiological assessment is necessary for the use of iENE in clinical trials, staging, and routine decision making. Using the HNCIG consensus classification in a binary format produced consistent results across international expert radiologists and imaging modalities, supporting its wider use. However, substantial variability remains in grading the extent of iENE, indicating the need for further training support.

BCL6, a transcription factor central to T follicular helper (TFH) cell differentiation, has recently been identified as a key regulator of T cell-mediated neuroinflammation. While previous research has established a connection between Th17 cells and B cell responses in autoimmune diseases, most notably in experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis-the role of BCL6 in T cell subsets beyond TFH cells remains unclear. In this study, we explored the impact of T...

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Nitrogen-containing heterocycles (N-Hets) are among the most prevalent and versatile structural motifs in pharmaceuticals, serving as key scaffolds in over 85% of biologically active small molecules. Their structural diversity and functional versatility have made them integral components of both U.S. Food and Drug Administration (FDA) approved and investigational drug molecules, modulating biological activity across a range of molecular targets. In 2025, the FDA approved 26 small-molecule drugs...