Laryngeal ossification is a form of heterotopic ossification widely recognized in humans and seldom reported in companion animals, with selected case reports available in domestic and wild animals. Through a retrospective multi-institutional study, we collected laryngeal specimens from canine and feline patients submitted for autopsy. The relevant clinical information, including age, breed, sex, weight and final diagnosis, was recorded in each case. Histological examination assessed the...

Natural products are a critical source of novel chemotypes for drug discovery. However, the implementation of natural product extract libraries in high throughput screening is hampered by natural product structural redundancy and potential for bioactive re-discovery. This challenge and large library sizes drastically increase the time and cost during initial high throughput screens. To address these limitations, we developed a method that leverages liquid chromatography-tandem mass spectrometry...

We propose protoacoustic radiography (PAR), an imaging modality combining proton excitation and acoustic detection for three-dimensional (3D) imaging from a single proton projection. PAR avoids the effect of multiple Coulomb scattering in imaging by detecting ultrasound. Proton-induced acoustic waves propagate spherically, enabling 3D imaging from a single projection. Additionally, the distinctive feature of proton beams-concentrating energy deposition primarily at the Bragg peak-allows for...

CONCLUSIONS: Nutritional indices may be valuable to predict adverse postoperative laryngectomy outcomes. Prospective studies are needed to validate these findings.

We present findings from town hall meetings held with ethnically diverse Black prostate cancer (CaP) survivors in 2022 and 2023. Four town halls (total participants, N = 265) focused on diagnosis, treatment, psychosocial support, and overall survivorship. Moderated by a long-term CaP survivor, each session featured a panel that included medical providers (urologic oncologists and clinical psychologists), as well as CaP survivors of American, Caribbean, and African origin and their spouses....