CONCLUSIONS: UGT1A1*28 homozygosity was not associated with increased toxicity in patients receiving NALIRIFOX in NAPOLI 3. These findings support the use of full NALIRIFOX dosing irrespective of UGT1A1*28 status.

Ecological momentary assessments (EMAs) and wearable devices afford opportunities to collect real-time data on events experienced in daily life. Examples of event-based data in the psychological and behavioral sciences include smoking a cigarette, experiencing a stressor, having a disruption to sleep, experiencing a depressive or manic episode, drinking an alcoholic beverage, or engaging in a bout of exercise. The increasing availability of dense sampling approaches allows for the measurement of...

There exists growing interest in integrating social and ecological sciences to elucidate human-nature interactions from the perspective of social-ecological systems (SES). The compelling logic in the past is that people inevitably harm nature as they use it; however, people have learned to use it while protecting or even improving it. Nowadays though there is a growing emphasis on transformability into a more desirable SES with deliberate human actions rather than adapting to the existing...

The translation of big data analytics and artificial intelligence (AI) into clinical decision support systems (CDSSs) has advanced from proof of concept to real-world clinical practice. AI-informed CDSSs show measurable improvements in diagnostic accuracy, risk stratification, resource use, and patient outcomes compared to traditional models, offering the potential to assist clinicians in managing symptom complexity and uncertainty in health care delivery. Despite this potential, access to large...

Working-From-Home (WFH) practices expanded rapidly during the COVID-19 pandemic and continue to be a point of discussion today with debates increasingly focused on productivity rather than the underlying reasons for WFH or flexibility. This study investigates why individuals value WFH and hybrid work arrangements in the United States. The specific period of study was during the COVID-19 pandemic. Understanding these motivations can inform constructive negotiations and effective policies that...