CONCLUSIONS: The evidence supporting amantadine use during acute hospitalization for stroke is limited and heterogeneous. While amantadine is commonly used to promote arousal in patients with impaired consciousness after stroke, available data do not allow firm conclusions regarding efficacy for functional recovery or mortality, and safety conclusions remain limited by inconsistent adverse-event reporting. Prospective, stroke-specific studies conducted in the acute hospital setting are needed to...

CONCLUSIONS: Aspiration thrombectomy alone may result in higher rates of successful reperfusion and reduce the need for rescue devices compared with the combined approach with IV thrombolysis.

CONCLUSION: Zanubrutinib was associated with a lower risk of AF/AFL, major bleeding, and all-cause mortality compared with Ibrutinib. These findings support the preferential use of Zanubrutinib when cardiovascular safety is a key consideration in patients with B-cell malignancies.

CONCLUSIONS: This study demonstrates wide variability in opioid prescribing patterns and attitudes among pediatric urologists. Despite growing evidence that opioids may not be necessary following pediatric urologic surgery, over half of pediatric urologists regularly prescribe opioids following hypospadias repair. Additionally, over half of the respondents believe opioids are over-prescribed. These findings represent an opportunity to improve opioid stewardship, which is meaningful given the...

CONCLUSIONS: Prophylactic LAAO during MVr in patients without AF may reduce thromboembolic events risk but appears to increase postoperative AF. Further randomized studies are warranted.