Glucose is an essential metabolic substrate for ATP production in virtually all life forms; however, due to its size and polarity, its cellular uptake requires specialized membrane transporters. The facilitative glucose transporters (GLUTs) are a conserved family of membrane proteins which facilitate the transport of glucose across the cellular plasma membrane. This family is evolutionarily conserved across phyla and ubiquitously expressed in mammalian tissues, positioning GLUTs as one of the...

Neurovascular coupling (NVC) is frequently disrupted after stroke, yet its temporal alignment and motor-network organization during sensorimotor engagement remain incompletely characterized. We tested whether chronic hemiparetic stroke alters the temporal alignment between EEG low-frequency oscillations (LFOs; 0.1-1.5 Hz) and the fMRI BOLD response during peripheral finger stimulation, and whether these alterations map onto motor-network anatomy and motor impairment. Simultaneous EEG-fMRI was...

CONCLUSIONS: The present substudy assessed the PK of everolimus delivered by Esprit BTK in the planned treatment of narrowed infrapopliteal lesions. This study confirms that the PK profile of everolimus eluted from the Esprit BTK scaffold results in limited systemic exposure and is considered to be safe and well tolerated.

Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers worldwide and carries substantial morbidity. Metformin, a widely used antidiabetic agent, shows promise for HNSCC prevention, but resistance arises in a subset of tumors. In a recent issue of Cancer Prevention Research, Hoang and colleagues use CRISPR screening to identify key mediators of metformin resistance, including AMPK and protein kinase A (PKA), and demonstrate that the cyclooxygenase 2-prostaglandin E2 axis...

The ADAMTS (a disintegrin and metalloproteinase with thrombospondin type-1 motifs) metalloprotease family comprises 19 members, and they play critical roles in development, angiogenesis and coagulation. These enzymes are also pivotal in the turnover of extracellular matrix proteins in various tissues, and their dysregulation has been linked to diseases such as arthritis, atherosclerosis, cancer and inflammation. These secreted zinc metalloproteases are composed of multiple domains and are...