CONCLUSIONS: When the internal jugular vein (IJV) and/or the common carotid artery (CCA) are used for access in children for VV-ECMO or VA-ECMO, there is a risk for a variety of neurological complications. If the CCA is repaired, a decision must be made about the need for long-term anticoagulation. If the IJV is ligated, particularly in neonates or young infants in whom cerebral autoregulation may not be fully developed, patients may be at higher risk of venous infarcts and intracranial...

ConspectusDeveloping systems that can efficiently capture photon energy and convert this energy into fuels and chemicals requires understanding how to assemble molecular components with diverse functions into complete systems possessing selectivity and efficiency in directing charge carriers to catalytic reactions. There are many challenges to achieving this goal. One promising approach is the development of hybrid systems that combine semiconductor nanocrystals (NCs) for light capture and...

The lymphatic vascular system plays essential roles in tissue fluid drainage, dietary fat absorption and transport, and immune cell trafficking. To support these physiological functions, the lymphatic vasculature forms an extensive and highly organized network throughout the body. We recently discovered that the mechanistic target of rapamycin complex 1 (mTORC1), with RAPTOR as an indispensable component, directs glycolysis and glutaminolysis in lymphatic endothelial cells (LECs) to promote...

Immune checkpoint inhibitors (ICI) can cause myocarditis, leaving physicians uncertain regarding the safety of restarting ICIs after recovery. This study aims to measure real-world incidence of ICI-induced myocarditis, and whether re-exposure to ICI after myocarditis impacts all-cause mortality. Adult patients with cancer treated with ICIs were identified from TriNetX network and outcomes were compared between patients re-exposed to ICI and those who were not.

Babesia microti is a tick-borne apicomplexan parasite of emerging public health importance, particularly in the northeastern United States. Current medications (e.g., atovaquone, azithromycin, clindamycin, and quinine) display limited efficacy and frequent adverse effects, underscoring the urgent need for safer and more potent therapies. In this study, we harnessed a computational drug design pipeline to develop novel sanguinarine derivatives targeting B. microti lactate dehydrogenase (BmLDH)-an...