Nicotinamide adenine dinucleotide (NAD^(+)) is one of the most important metabolic coenzymes that not only drives redox reactions and energy production but also acts as a critical substrate for several enzymes involved in immune signalling, DNA repair and epigenetic regulation. Viral infections are known as potent modulators of NAD^(+) metabolism, with pathogens such as SARS-CoV-2, influenza A virus, Zika virus, herpes simplex virus and human immunodeficiency virus altering NAD^(+) biosynthesis...

As systemic therapies for non-small cell lung cancer (NSCLC) have become more effective, interest in their use for improving long-term surgical outcomes has rapidly increased. Imperfect as it is, stage remains the primary means for identifying patients who might benefit from systemic therapy. Recent clinical trials have led to US Food and Drug Administration approval of osimertinib and alectinib as adjuvant treatments for resected pathologic stage II/III EGFR and ALK-mutated NSCLC; their use in...

Lockie, RG, Dawes, JJ, Campana, T, Kramer, J, Orr, RM, and Romero, M. Relationships between isometric midthigh pull, body mass, countermovement jump, upper-body muscular endurance, and intermittent running with job task performance in firefighter trainees. J Strength Cond Res 40(7): 815-821, 2026-Maximal strength is essential for firefighters but may be challenging to measure in this population because of time constraints, injury risk, and ability variations. The isometric midthigh pull (IMTP)...

Recent literature suggests that vicarious racism is linked to adverse psychological health outcomes. However, our understanding of protective and risk factors in this context remains limited. This study examined the relationships among social media use integration, vicarious racism, individual differences (race-based rejection sensitivity and racial centrality), and psychological outcomes (anxiety and depression) in a sample of Black American adults. We hypothesized that higher social media use...

BackgroundPeritoneal dialysis (PD)-associated peritonitis remains a leading cause of hospitalization, technique failure, and transfer to in-center hemodialysis, with touch contamination during connections accounting for many episodes. Although shrouded connectors and "flush before fill" mechanisms reduce contamination risk, most automated peritoneal dialysis (APD) systems incorporate recessed fluid paths on only one side of the tubing-bag interface, potentially allowing bacterial transfer. We...