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AXL is overexpressed in many cancers, including breast, lung, colon, osteosarcoma, kidney, stomach, and gliomas, and associated with poor patient survival and plays an important role in cancer cell proliferation, survival, tumor growth, progression and metastasis. In vivo studies involving genetic targeting of AXL validated it as a promising therapeutic target. In this study, we performed integrated in silico analyses, including virtual screening, molecular docking, molecular dynamics (MD)...

Caveolae are specialized plasma membrane invaginations implicated in ocular diseases including primary open angle glaucoma, diabetic retinopathy and age-related macular degeneration. Caveolin-1 (CAV1) typically functions within caveolae where it associates with a co-regulatory protein, CAVIN1 (also known as polymerase I and transcript release factor; PTRF), which is necessary for caveolae formation. However, CAV1 can also reside outside of caveolae in planar "scaffolds," though the function of...

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