CONCLUSIONS: Hypertension disrupts skeletal muscle metabolic homeostasis and muscle-vascular communication, driven in part by persistent lactate accumulation and altered protein lactylation. Targeting lactate-mediated signaling may offer new therapeutic avenues for hypertensive vascular dysfunction.

Native tallgrass prairies once covered much of the North American Great Plains but have largely been converted to agriculture and other land uses. The remaining areas of native prairie thus serve as critical benchmarks for understanding global change. Konza Prairie Biological Station (KPBS) is located within one of the largest remaining areas of native tallgrass prairie. Streams within the biological station are characterized by hydrologic extremes, including prolonged periods of drying in some...

A growing number of social scientists are using ecological momentary assessment (EMA) to observe how social forces operate in real time. However, the validity of EMA for measuring features of daily life-what people are doing, where, and with whom-remains uncertain. A key challenge is the lack of consensus across studies about how validity in EMA methods is defined and assessed. The authors address that gap by comparing EMA data (n = 1,174) with time diary data (n = 1,113) using two...

CONCLUSIONS: Although CHF RCTs are the gold standard for evaluating new interventions, many fall short in pragmatism, information value, power analysis, and data transparency. Future trials may benefit from prioritizing pragmatic principles, adequate power calculations, cost analysis, and data sharing.

CONCLUSION: Patients with temporal bone fractures who can safely follow-up as outpatients without inpatient otolaryngology consultation can be effectively identified. This will decrease unnecessary inpatient consultation volumes, optimize primary team workflow, and may result in potential cost savings.