Advanced and treatment-refractory prostate cancer, including castration-resistant disease, require new therapeutic strategies. TRPM4, a calcium-activated monovalent cation channel, regulates cell volume and promotes cancer progression. Acetalax induces oncosis-like death in TRPM4-positive triple-negative breast cancers, suggesting a TRPM4-dependent vulnerability. Here, we investigated whether TRPM4 expression defines Acetalax sensitivity in prostate cancer. We compared Acetalax sensitivity in...

INTRODUCTION: American Indians and Alaska Natives have lower life expectancies, and poorer oral health compared to other US populations. These negative health outcomes are somewhat preventable with routine care, but provider shortages, proximity to health services, and other factors create barriers. The Community Health Aide Program (CHAP) is a multidisciplinary system of certified mid-level behavioral, medical, and dental providers working alongside licensed providers to increase access to...

Exponential growth in global computing demand is further exacerbated by the high energy requirements of conventional architectures, which are dominated by costly data movement requirements. In-memory computing with Resistive Random Access Memory (RRAM) addresses this challenge by co-integrating memory and processing, but faces tremendous hurdles related to device-level non-idealities and offers poor scalability in large computing tasks. Here, we introduce MELISO+ (In-Memory Linear Solver), a...

Soils are critical reservoirs of antibiotic-resistance genes (ARGs)^(1,2), which are strongly shaped by microbial interactions and environmental conditions and are therefore highly sensitive to disturbance^(2-6). Although climate warming is recognized as one of the most significant disturbances to microbial communities and their functions^(7-10), its impacts on soil resistomes remain poorly understood. Here we investigated the effects of decade-long experimental warming on ARGs in grassland...

Long non-coding RNAs (lncRNAs) regulate multiple cellular processes. However, knowledge of the responses and regulatory functions of lncRNAs in physical exercise and training remains limited. As part of the Molecular Transducers of Physical Activity Consortium (MoTrPAC), we conducted a comprehensive analysis of lncRNA expression patterns in 18 tissues after an 8-week progressive endurance training program in rats. The lncRNA expression pattern was largely tissue-specific. In total, 759 unique...