INTRODUCTION: Chatbots using large language models such as ChatGPT, Google Bard, etc., have become increasingly popular in recent years. The chatbot's ability to simulate conversations with users and process input data and respond based on that information has prompted researchers to investigate the applicability of chatbots in decision-making processes across multiple fields. Current literature has investigated the benefits and challenges of using chatbots in a broad context. This paper...

Glycosylation is a pivotal post-translational modification that influences protein folding, stability, and interactions, with direct implications for muscular dystrophy pathogenesis and emerging gene therapies. Sarcoglycans (SGs), β-, δ-, γ-, and α-subunits of the dystrophin-glycoprotein complex (DGC), contain essential N-linked glycosylation sites, and mutations that disrupt glycan attachment, destabilize the complex and cause limb-girdle muscular dystrophy. Yet, the structural consequences of...

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CONCLUSION: MA enrollment was associated with lower odds of timely NHT initiation compared with TM. These associations were particularly evident among underserved groups, highlighting the need to evaluate how MA program structures may influence equitable access to evidence-based cancer care.

CONCLUSIONS: The mGWAS of Asian Indians offers new insights into the diverse molecular origins of cardiometabolic diseases and suggests potential pathways for innovative treatments. Our findings highlight the need for additional research on human lipidomics to better understand the downstream effects of the genome and its impact on cardiometabolic health.