CONCLUSIONS: Across a heterogeneous evidence base, integrating LAT into first-line EGFR TKI therapy is associated with improved PFS and OS with acceptable toxicity. These findings support further prospective investigation to better define patients election, optimal timing, and integration with contemporary systemic combination strategies.

CONCLUSIONS: Comprehensive evaluation incorporating imaging characterization, hormonal testing, and growth surveillance provides an evidence-based framework for safe management of adrenal incidentalomas. Recent randomized controlled trials support expanded surgical indications in carefully selected MACS patients, particularly those with documented comorbidities, demonstrating superior cardiovascular and metabolic outcomes compared with medical management alone. The paradigm has shifted from...

Microcins are bacterially produced peptide antimicrobials. In a recent work, Telford et al. discover an Acinetobacter baumannii amyloid-like microcin that is also a structural component of the biofilm matrix. Might cells turn biofilms into 'minefields' to keep competitors from closing in?

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Skeletal editing enables precise structure modifications by inserting, deleting, or rearranging atoms to achieve diversification. Building on previous computational studies that highlighted the potential for cycloreversion of trans-cyclohexenes as a means of diene synthesis, and motivated by our ongoing interest in molecular transducers, we present the first experimental evidence for the retro-Diels-Alder reaction of trans-4-phenyl-3,6-dihydro-2H-pyran. Energy transfer photocatalysis leads to...