The impact of complex coronary anatomy on outcomes in patients at high bleeding risk (HBR) undergoing percutaneous coronary intervention (PCI) remains unclear. Patients from a large PCI referral center were labeled as HBR in presence of ≥1 major or ≥2 minor Academic Research Consortium HBR criteria and undergoing complex PCI if they had any of the following: ≥3 vessels treated, ≥3 stents implanted, ≥3 lesions treated, stent length >60mm, bifurcation lesion with ≥2 stents, PCI of chronic total...

CONCLUSION: Our objective was to characterize whole-body lactate metabolism in AD, an understand how lactate might affect cognition. We found that lactate infusion reduced BD-tau, phosphotau species, GFAP, and NfL which could be due to systemic or brain-based changes in proteostasis. Biomarker changes were not explained by change in plasma volume or kidney function, and only brain-specific biomarkers were affected. Additional analyses are planned to investigate the relationship of lactate and...

CONCLUSION: This guide synthesizes clinical insights and practical guidelines to support neurosurgical trainees and practitioners in mastering cerebrovascular bypass techniques.

Biodiversity collections in the United States hold over a billion specimens and are essential to understanding the history of life on Earth, as well as patterns of biodiversity in response to environmental change. Each specimen is linked by metadata to an organism's name and the place and time of its collection. Extensive data have been collected on Earth's geology, hydrology, climate, and organisms-past and present-but the data remain largely fragmented. We report in the present article on...

MRI is central to evaluating skull-base lesions, but morphologic features alone can misclassify vascular anomalies as neoplasms. A 27-year-old man presented with left monocular diplopia and an enhancing dural-based lesion along the lateral-superior wall of the left cavernous sinus, read as a sphenoid-wing meningioma. He was evaluated for stereotactic radiosurgery. Incorporation of ^(68)Ga-DOTATATE PET demonstrated no somatostatin receptor avidity, prompting neuroradiology re-review of prior...