CONCLUSIONS: In this large ELSO registry analysis, VP ECLS was chiefly used for HF/CS and ARF/ARDS. Hospital outcomes, complications and survival differed according to the diagnosis leading to VP ECLS use. Younger age, male sex, lower BMI, and no CRRT use prior to VP ECLS cannulation confer a lower risk of death and provide targets for future research and potential domains for clinical improvement.

Cancer cells face a hostile microenvironment characterized by hypoxia, nutrient deprivation, endoplasmic reticulum (ER) stress, and oxidative imbalance. To cope with these challenges, they activate an interconnected network of adaptive pathways including autophagy, the unfolded protein response, metabolic reprogramming, and the integrated stress response., which promote cell survival, therapy resistance, immune evasion, and metastasis. CRISPR-based functional genomics has emerged as a powerful...

Emotional thought patterns such as rumination, worry, and positive reflection are rooted in autobiographical memory and influence well-being. However, their neural representations and how they vary remain poorly understood. This study examined brain activation patterns linked to rumination, worry, and positive thinking in adults aged 18-64. Participants recalled autobiographical events during fMRI, and machine learning was used to decode whole-brain activation patterns. Results showed that...

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CONCLUSIONS: The planning, development, and implementation of the program demonstrates that implementation science-based efforts can produce strategies that address systemic barriers to contraceptive access. Aligning payer policies, coalition-building, and responsive training are all key activities of the program and process adaptations and lessons learned have contributed to the continued viability of the program.