Sleep is vital to human health, and poor sleep health has been associated with numerous chronic conditions, including cardiovascular disease, obesity, depression, and type 2 diabetes. Recently, an emerging area of research has focused on the relationship between dietary polyphenols and sleep health. This connection may be mediated by the gut microbiota and polyphenol-derived microbial metabolites, which also exert biologically relevant effects. One such metabolite, urolithin A, has been shown to...

Age-related macular degeneration (AMD) remains a leading cause for visual impairment in the elderly. We recently showed that activated mammalian target of rapamycin complex 1 (mTORC1) in photoreceptor cells causes AMD-like pathologies in mouse. Employing mouse genetics, we dissect the mTORC1 pathway and identify ribosomal protein S6 kinase beta-1 (S6k1) as a key component required for disease onset in our mouse model. Using a previously identified fully chemically modified tetravalent small...

BACKGROUND: Proximal humerus fractures (PHFs) often occur in an elderly population at-risk for complications following surgery. However, it is unknown whether acute pre-operative metabolic and nutritional (M + N) variables vs. more chronic frailty evaluation is better linked to these poor outcomes. The purpose of this study is to compare the associations of the M + N index vs. frailty with the outcomes of surgical intervention for PHFs.

CONCLUSION: OAB is independently associated with an increased risk of a recent fall in US adults aged 20-69 years, with a strong positive relationship between OAB severity and fall risk. These findings suggest that screening for OAB may be a useful adjunct to fall risk assessment. Future studies are needed to determine whether OAB management reduces the risk of falls.

CONCLUSIONS: The study highlights key drivers behind the variation in state-level opioid policy comprehensiveness, offering a clearer picture of how political and contextual factors influence public health policymaking. These insights can guide future research on state-level health policy adoption.