We sought to examine whether global structural changes in grey and white matter predict adolescent internalizing symptoms using a 3-year longitudinal design. Using secondary data analysis from the Adolescent Brain Cognitive Development Study, 6,564 participants (53% male, 55% White) were included in analyses. We used linear mixed-effects models to predict adolescent internalizing symptoms (measured at ages 12/13 via caregiver report and self-report) from structural brain metrics. Percent change...

Background: Reproductive health, including abortion care, is a critical component of undergraduate medical education (UME) that is inconsistently included in UME. Objective: The objective of this study is to investigate the association between the inclusion of abortion and contraception topics in UME curricula overall and state-level abortion restrictions. Methods: A national cross-sectional survey of medical students was conducted from August 2022 to June 2023 using the American Medical Student...

CONCLUSIONS: In pediatric CNS tumors, ICIs provide limited benefit outside select molecularly defined subgroups. Although toxicities are generally manageable, evidence remains insufficient to support routine clinical use. Future efforts should emphasize biomarker-driven selection and combination regimens.

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CONCLUSIONS: Social support from offline social contexts are more foundational and paramount to promoting positive psychological adjustment than online social support. Online engagement in trans young adults is individualized and offers a variety of supportive and unsupportive experiences.