No abstract

The global aging population presents significant challenges to public health systems, particularly in countries like Hungary, which faces some of the least favorable health indicators in the European Union. To address these challenges, Purpose in Life (PIL) has emerged as a critical determinant of healthy aging, influencing physical, mental, and social health. Defined as a sense of meaning, direction, and intentionality, PIL promotes resilience, mitigates age-related decline, and fosters...

CONCLUSIONS AND RELEVANCE: In this unblinded randomized clinical trial, PCC had superior hemostatic efficacy and safety advantages to frozen plasma among patients requiring coagulation factor replacement for bleeding during cardiac surgery.

No abstract

Anxiety disorders, affecting approximately one in nine individuals globally, impose significant socioeconomic and health burdens, with many individuals failing to achieve symptom remission despite standard treatments. Difficult-to-Treat Anxiety (DTA) encompasses a broad spectrum of persistent anxiety disorders that remain refractory to conventional interventions, necessitating a shift from rigid response-based criteria to a mechanistically driven framework integrating computational psychiatry...