CONCLUSIONS: This review highlights gaps in the literature about IBD in Indigenous populations. While the prevalence of IBD among Indigenous peoples is low, rates may be rising. Further research should continue studying the rising rates of IBD in Indigenous populations, alongside contributing genetic and environmental factors. Indigenous peoples must be included as research partners, and Indigenous research methodologies must be adhered to.

BACKGROUND: Shoulder surgery is a significant subset of orthopedic interventions, and randomized controlled trials (RCTs) are critical for advancing surgical techniques and informing clinical guidelines. However, poorly designed or inadequately reported RCTs make applying findings to clinical practice more difficult. This study applies a usefulness assessment tool developed by van 't Hooft et al to evaluate the utility of shoulder surgery RCTs published in the past 5 years, aiming to identify...

Cancer diagnoses are prevalent in people with obesity and type 2 diabetes, and abundant clinical evidence supports the protective effects of weight loss for cancer prevention. Glucagon-like peptide-1 (GLP-1) receptor agonists have revolutionized obesity and type 2 diabetes medicine and alleviate many comorbidities of these metabolic diseases. In this Review, we summarize the current clinical evidence for GLP-1 receptor agonists and cancer risk, including thyroid, pancreatic, gastrointestinal,...

Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification mediated by ADP-ribosyltransferases, known as PARPs, which attach ADP-ribose units onto proteins, forming negatively charged multimeric chains. This modification relaxes chromatin at DNA damage sites, facilitating repair machinery access. Additionally, PAR polymers serve as docking platforms for effector proteins, termed PAR "readers", commonly involved in DNA repair. The recruitment of these proteins is mediated through...

Sanchez, KJ, Baruch, T, Ross, KA, Coburn, JW, Costa, PB, Orr, RM, Dawes, JJ, and Lockie, RG. Coronary artery calcium status, body composition, blood lipids, and fitness among firefighters participating in a health and wellness program. J Strength Cond Res XX(X): 000-000, 2025-Cardiovascular disease (CVD) is prevalent among firefighters. Coronary artery calcium (CAC) can contribute to the identification of CVD risk, but there has been limited analysis in firefighters. This study investigated body...