Self-similarities at different time scales embedded within a self-organizing neural manifold are well recognized. In this study, we hypothesize that the Hurst fractal dimension (HFD) of the scalp electroencephalographic (EEG) signal reveals statistical differences between chronic pain and opioid use. We test this hypothesis by using EEG resting state signals acquired from a total of 23 human subjects: 14 with chronic pain, 9 with chronic pain taking opioid medications, 5 with chronic pain and...

CONCLUSIONS: Findings suggest that interventions promoting healthier coping strategies and increasing access to inclusive social and recreational spaces may help reduce tobacco use among rural female SMYAs.

CONCLUSION: This review synthesizes previous work to increase understanding of the integration of dental health aides, through the CHAP Framework. Findings outline the key oral health workforce concepts to increase access to oral healthcare through a culturally adapted approach.

Systematic analysis of the fate of hydrogel nanoparticles after in vivo administration is essential for their clinical translation. Biodegradable, disulfide-crosslinked synthetic nanogels are a promising platform for the delivery of therapeutic molecules, but their biodistribution and clearance profiles remain underexplored compared to other solid nanoparticles. In this study, we investigated the safety, pharmacokinetics, tissue, and cellular distribution profiles of...

Nitrogen-related phosphotransferase (PTS^(Ntr)) systems are highly conserved and widely distributed in proteobacteria. These systems are thought to enable bacteria to sense and respond to changes in cellular carbon and nitrogen availability. The PTS^(Ntr) is analogous to the carbohydrate phosphotransferase systems that carry out phosphorylation and uptake of specific carbohydrates. Instead of targeting carbohydrates, the PTS^(Ntr) influences metabolic flux, virulence, biofilm development, stress...