Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced impaired antiviral immunity and excessive inflammatory responses cause lethal pneumonia. However, the in vivo roles of key pattern recognition receptors that elicit protective antiviral and fatal inflammatory responses, specifically in the lungs, are not well described. Coronaviruses possess single-stranded RNA genome that activates TLR7/8 to induce an antiviral interferon (IFN) and robust inflammatory cytokine response. Here,...

We report the genome sequence of phage Sourignavong isolated from soil in Oklahoma City, Oklahoma using Arthrobacter sp. ATCC 21022. The 15,625 bp genome contains 27 predicted protein coding genes, including two predicted endolysin enzyme genes. Sourignavong is assigned to actinobacteriophage cluster AN.

This study explores the nonlinear optical (NLO) properties of two synthesized copper complexes, {[Cu(dmp)(2)(H(2)O)]·(PA)(2)} (complex 1) and {[Cu(dmp)(2)]·(PA)} (complex 2), where dmp represents 2,9-dimethyl-1,10-phenanthroline (neocuproine) and PA refers to picric acid. Employing both experimental and theoretical approaches, we comprehensively analyzed their NLO properties. Experimentally, third-order NLO parameters were determined using the Z-scan technique with a 520 nm continuous-wave diode...

CONCLUSION: The FUVID study will investigate the relationship between symptoms (exercise intolerance and exertional dyspnea) and multiple mechanisms-hemodynamic, ventilatory, or peripheral/muscle-within the same patient at rest, submaximal exercise (simulating activities of daily living), and maximal exercise using objective measures. It will provide new evidence for selecting patients for long-term follow-up, including psychological sequelae, after PE, the modalities this follow-up should...

In recent years, foul odors have led to widespread public complaints and have become a prominent issue in the field of environmental protection. Skatole, as one of the important components of foul odors, is a decomposition product of tryptophan in the intestines of animals and is mainly found in animal feces. Skatole not only has significant pulmonary toxicity to animals but also poses potential carcinogenic risks to humans. The biological method of removing skatole has the notable advantages of...