Hydrophobic bile acid-mediated hepatobiliary injury is a major driver of cholestasis progression. Most anti-cholestasis treatments being tested clinically are based on a single agent, which does not always sufficiently alleviate bile acid toxicity to slow disease progression. This study investigates a therapeutic strategy of combining glycine-conjugated β muricholic acid (Gly-βMCA) and fibroblast growth factor-15 (FGF15) to alleviate bile acid hepatobiliary toxicity in Cyp2c70 KO mice that lack...

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Oral and Maxillofacial Surgery (OMS) residency programs in the United States have recently experienced a notable decline in match rates. While it may be challenging to identify the root cause of this change, similar experiences in other specialties have identified contributing factors such as the increase in the number of residency positions, changes in specialty perception and workforce needs as contributing factors. This article examines the current state of OMS residency training and provides...

Supraventricular tachycardia (SVT) is commonly seen in children with structurally normal hearts. Understanding the possible mechanisms of SVT, including re-entry, enhanced automaticity, and triggered activity, and their associated responses to common therapeutic modalities can aid the clinician in tailoring the acute management strategy. Acute management of SVT is dependent on patient stability and the likely arrhythmia substrate. The overall prognosis for children with SVT is favorable with the...

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