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CONCLUSIONS AND RELEVANCE: After major vascular or general surgery operations among patients at high risk of a cardiac event, a liberal transfusion strategy did not reduce 90-day death or major ischemic outcome rates compared with a restrictive strategy.

CONCLUSION: In this audit, the dCHPM was associated with timely closure and favourable safety outcomes in real-world practice. These descriptive findings may contribute to the growing body of real-world evidence supporting full-thickness placental membranes as adjuncts to SoC in the treatment of hard-to-heal ulcers.

Substance Use Disorder (SUD) is a chronic, relapsing condition driven by complex neurobiological changes, many of which are mediated by post-translational modifications (PTMs). These chemical alterations regulate receptor activity, intracellular signaling, and chromatin structure, shaping the neuroadaptations associated with SUD and relapse. This review emphasizes the central role of PTMs in modulating protein stability and function, contributing to drug-induced changes in key brain regions such...

To reside in marine habitats, marine fishes must actively eliminate the excess Na+ and Cl- they acquire from their environment. These ions are passively absorbed across body surfaces and through the ingestion of seawater (SW), which is necessary to maintain water balance. Salt secretion occurs through the actions of mitochondrion-rich 'SW-type ionocytes' in the gills or other specialized salt-secreting organs. For nearly 50 years, the SW-type ionocyte model proposed by Patricio Silva and...