CO(2) utilization is a significant and emerging field in catalysis, playing a crucial role in reducing atmospheric CO(2) and mitigating climate change. In this work, we report on Cu(i) complexes that utilize atmospheric CO(2) for the direct carboxylation and esterification of terminal alkynes. The Cu(i) complexes bear ligands of the type 2,6-bis(3-alkyl/arylimidazol-2-ylidene) methylpyridine I(R)^(C^N^C), where R = ^(i)Pr, Me, 2,6-^(i)Pr(2)Ph (Dipp), 2,4,6-Me(3)Ph (Mes), and 4-CF(3)Ph. While...

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The neonicotinoid insecticide, imidacloprid (IMI), is one of the widely used pesticides with well-documented serious health effects that are noticeable with long-term exposure. However, the long-term effects of IMI on cardiac tissues have not been fully elucidated. Herein, we investigated the mechanisms of IMI-induced cardiotoxicity. Additionally, we examined the potential protective effects of the natural alkaloid, berberine (BBR), against IMI-induced cardiotoxicity. Rats received IMI (45...

Lower gastrointestinal graft-versus-host disease (LGI-GVHD) carries morbidity and mortality for patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT), with critical contributions from the intestinal microbiome. In a retrospective cohort of metagenomic sequencing of allo-HSCT patient stool (n = 90), we found that a reduction in specific Parabacteroides and Bacteroides species around the time of engraftment contributes to LGI-GVHD risk. Given the known diverse...