Proteoforms, the endogenous forms of proteins that take into account all sources of variation (genetic as well as co- and post-translational), may be more relevant for understanding complex biological mechanisms, including disease phenotypes, than generically defined "protein families". Mass spectrometry-based top-down proteomics often utilizes electrophoretic techniques that rely on sodium dodecyl sulfate (SDS) to fractionate proteoforms prior to liquid chromatography-tandem mass spectrometry...

PURPOSE OF REVIEW: Cardiac autonomic dysfunction plays a crucial role in the pathogenesis of common cardiovascular diseases. The review discusses current and emerging techniques in the evaluation of cardiac autonomic tone.

ConspectusLiquid environments play a crucial role in the biological processes occurring in living organisms as well as in many human-made processes involving electrochemistry, photo-, and thermocatalysis. In the majority of these systems, aqueous phases are ubiquitous due to water's natural abundance. Water molecules, however, can exert large changes in the chemical environment of catalytically active sites, altering the reaction rates, selectivity, and catalyst stability. These solvation...

A nutritious diet is an important protective factor against hypertension and cardiovascular disease. However, there are substantial barriers to healthy eating within American Indian (AI) communities resulting from colonization, the effects of which are still present today in systemic inequities. To address these inequities, many AI communities work toward restoration of access to and knowledge of traditional (i.e. pre-colonial) foods. The Chickasaw Healthy Eating Environments Research Study...

No abstract