As local spatial cues, angle and length information are known to be effective cues for relocation in adults, yet young children often struggle with using such information. We propose that the previously found late utilization of local geometric cues might be partly attributed to the testing environments, where connected enclosures provided immediate access to its global shape. Here, we investigated at what age children acquire the ability to relocate using local angle and length information in...

CONCLUSION: In PROC patients with prior bevacizumab, all experimental arms failed to reach the primary objective of improving PFS compared with SOC.

We experimentally and theoretically demonstrate that spinor gases driven by spin-flopping fields are excellent platforms for investigating ergodicity breaking and quantum scarring. We observe that specific initial states remain nonthermal at weak driving despite the majority of states thermalizing, which constitutes clear evidence of quantum many-body scars (QMBSs). As the driving strength increases, the experimental system undergoes a smooth transition from integrable to weakly ergodicity...

Invisible axion models that solve the strong CP problem via the Peccei-Quinn (PQ) mechanism typically have a quality problem that arises from quantum gravity effects which violate all global symmetries. These models therefore require extreme fine-tuning of parameters for consistency. We present a new solution to the quality problem in a unified SO(10)×U(1)_{a} gauge model, where U(1)_{a} is an anomaly free axial gauge symmetry. PQ symmetry emerges as an accidental symmetry in this setup, which...

High cardiorespiratory fitness and exercise show evidence of altering bile acid (BA) metabolism and are known to protect or treat diet-induced hepatic steatosis, respectively. Here, we tested the hypothesis that high intrinsic aerobic capacity and exercise both increase hepatic BA synthesis measured by the incorporation of 2H2O. We also leveraged mice with inducible liver-specific deletion of Cyp7a1 (LCyp7a1KO), which encodes the rate-limiting enzyme for BA synthesis, to test if exercise-induced...