CONCLUSIONS: Mirdametinib demonstrated deep and durable tumor responses, significant improvement in pain and HRQoL, and manageable safety in adults and children, underscoring mirdametinib's potential to become an important new NF1-PN treatment option. Disclaimer: Abstracts were not reviewed by Neurology® and do not reflect the views of Neurology® editors or staff. Disclosure: The institution of Dr. Shuhaiber has received research support from SPRINGWORKS . The institution of Dr. Shuhaiber has...

CONCLUSIONS: The agreement between the Predicted and Treated groups was majority within the limits. The predictions of the digital system were not accurate in some parameters; however, most of the differences were within clinical acceptable range. Although there are some inaccuracies, the limitations do not seem to interfere with clinical outcomes and the quality of the treatment.

Aging is associated with a progressive decline in circulating insulin-like growth factor- 1 (IGF- 1) levels in humans, which has been implicated in the pathogenesis of sarcopenia. IGF- 1 is an anabolic hormone that plays a dual role in maintaining skeletal muscle health, acting both directly on muscle fibers to promote growth and indirectly by supporting the vascular network that sustains muscle perfusion. However, the microvascular consequences of IGF- 1 deficiency in aging muscle remain poorly...

CONCLUSION: The proposed explainable Transformer-based deep survival model shows strong potential for providing accurate patient-specific survival predictions for ALL. Moreover, the insights gained from SHAP improve the model's interpretability for clinicians, helping them make better-informed decisions regarding prognosis and treatment.

Delaying the initiation of cancer treatment increases the risk of mortality, particularly in colorectal cancer (CRC), which is among the most common and deadliest malignancies. This study aims to explore the impact of treatment delays on mortality in CRC. A systematic literature search was conducted in PubMed, Web of Science, and Scopus for studies published between 2000 and 2025. Meta-analyses were performed using random-effects models with inverse variance method to calculate hazard ratios...