No abstract

Cervical cancer elimination (<4 cases per 100,000) is a critical cancer prevention goal in the United States. Implementation of health policies and allocation of health resources occur at regional and state levels; therefore, understanding region- and state-specific cervical cancer incidence, mortality, and progress towards elimination-and remaining gaps-is essential. We estimated hysterectomy-corrected cervical cancer incidence, mortality, and progress toward elimination across all 50 states,...

No abstract

CONCLUSIONS AND PRACTICAL IMPLICATIONS: Clinicians should base imaging decisions on the patient's medical and dental histories, clinical examination findings, disease risk assessment, and the presence of specific clinical conditions. When used appropriately, radiographic imaging contributes to dental treatment decisions and results in optimal patient care.

Heme is an essential cofactor and dietary source of iron for the obligate human pathogen, Mycobacterium tuberculosis (Mtb). Consequently, heme is required for Mtb growth and pathogenicity and strategies to limit heme represents a promising therapeutic approach. Although Mtb can both make and scavenge heme, it was previously found that de novo synthesized heme is substantially more bioavailable and metabolically active than exogenously scavenged heme. These findings provided a strong...