Sjögren's disease (SjD) is the second most common systemic autoimmune disease in the United States. SjD patients are predominantly women 30-50 years of age and exhibit heterogeneous clinical manifestations, including symptoms of extensive dryness, chronic fatigue, and joint pain, and various major organ involvement. Late onset, clinical heterogeneity, and limited mechanistic understanding of its etiology frequently lead to delayed or misdiagnosis. Although the etiology of SjD is unclear,...

EAI141 was a prospective, multi-center trial designed to assess 3'-deoxy-3'-^(18)F-fluorothymidine (FLT) PET/CT as a treatment response biomarker. The primary objective was to evaluate the negative predictive value (NPV) of post-treatment 'day 14' FLT-uptake (clinically non-responding patients with high FLT uptake). Among 87 patients enrolled from 9 centers, 61 were evaluable for the primary endpoint. The NPV for FLT PET/CT was 0.20 (3/15, 95% CI 0.04-0.48) compared to the NPV for nadir bone...

CONCLUSIONS: PFKFB2 is essential for fed-to-fasted changes in cardiac metabolism and plays an important regulatory role in protein O-GlcNAcylation. Its loss also affects systemic glucose homeostasis under stressed conditions.

CONCLUSIONS: In this multi-institutional database study using FSS scores to describe a contemporary, heterogeneous patient population with recurrent PICU-based observations of functional status, we identified six classes of outcome trajectories with different clinical and demographic characteristics.

Females communicate non-genetic information about the environment to their developing offspring to generate potentially adaptive phenotypic variation. For example, birds allocate steroid hormones to their egg yolks in response to social stimuli and these hormones can induce long-lasting changes to offspring physiology and behavior. However, little work has explored how multiple yolk steroids respond to social challenges, despite their shared biosynthetic pathway, or how they impact early...