No abstract

Dietary fat composition has changed substantially during the obesity epidemic. As adipocyte hyperplasia is a major mechanism of adipose expansion, we aim to ascertain how dietary fats affect adipogenesis during obesity. We employ an unbiased dietary screen to identify oleic acid (OA) as the only dietary fatty acid that induces obesogenic hyperplasia at physiologic levels and show that plasma monounsaturated fatty acids (MUFAs), which are mostly OA, are associated with human obesity. OA...

CONCLUSION: There was an initial decline in mortality, however, a rise was observed in recent years. NHAI have the highest AAMR. Higher AAMR are observed in males, in the South and West, and in rural areas. We emphasize the need for targeted interventions addressing these disparities by improving access to resources, surveillance, and management strategies for this vulnerable population.

While repair of complete atrioventricular septal defects (CAVSD) has shown excellent results, the need for left atrioventricular valve (LAVV) intervention after the initial CAVSD repair presents therapeutic challenges and potential morbidity. Data on incidence and outcomes of LAVV intervention after primary CAVSD repair remain limited. Retrospective review of the Pediatric Health Information System (PHIS) from 1/2004 to 12/2023. All patients who underwent CAVSD repair were included. LAVV...

Sleep disorders, particularly insomnia and obstructive sleep apnea, are increasingly implicated as significant contributors to cognitive decline, dementia, and neurodegenerative diseases such as Alzheimer's disease (AD) and vascular cognitive impairment and dementia (VCID). However, the extent and specificity of these associations remain uncertain. This meta-analysis evaluates the impact of common sleep disorders on the risk of developing dementia and cognitive decline. A comprehensive search of...