Periodontitis is a chronic bacterial infection that destroys the epithelial attachment, forming a crevice beneath the gingival margins. The bacteria form dentally attached biofilms that enter the crevice and cause systemic inflammatory diseases (comorbidities). Susceptibility to moderate or severe (established) periodontitis is associated with smoking, diabetes, inadequate oral hygiene, and a genetic factor related to innate immunity function. One key factor in innate immunity function and its...

Colorectal cancer (CRC) remains a major global health challenge, with chronic inflammation and disruption of epithelial polarity identified as key drivers of tumor progression. Polarity complexes such as Scribble-Mutated in Colorectal Cancer (MCC) are central to maintaining epithelial homeostasis, and their dysregulation has been linked to oncogenic transformation. Drug repurposing offers a promising strategy to accelerate therapeutic discovery by identifying new applications for clinically...

CONCLUSIONS: Among patients with significant MR, the AltaValve TMVR system was feasible, safe, and associated with good valve function at 6 months. (AltaValve Early Feasibility Study Protocol; NCT03997305).

This study evaluated the effects of ibogalogs on recognition and spatial memory in rodents, focusing on potential hippocampal mechanisms. The Barnes maze study demonstrated that ibogaminalog (DM506) and ibogainalog (IBG) improved short- (30 min) and long-term (24 and 72 h) spatial memory in mice, whereas tabernanthalog (TBG) showed less efficacy. The novel object recognition task (NORT) results showed that DM506, but not TBG or IBG, enhanced long-term (24 h) recognition memory. Serotonin type 2...

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by antinuclear antibodies (ANAs). Epstein-Barr virus (EBV) infection has been epidemiologically associated with SLE, yet its role in pathogenesis remains incompletely defined. Here, we developed an EBV-specific single-cell RNA-sequencing platform and used it to demonstrate that EBV infection reprograms autoreactive antinuclear antigen B cells to drive autoimmunity in SLE. We demonstrated that, in SLE, EBV^(+) B...