Significant genetic heterogeneity has hindered the identification of molecular targets and development of effective targeted therapies for triple negative breast cancer. Currently available targeted therapies are not curative for TNBC patients. Eukaryotic Elongation Factor-2 kinase (eEF2K) is a clinically significant proto-oncogenic therapeutic target linking this atypical alpha kinase to poor patient survival and a key driver of tumor growth and progression in TNBC, positioning it as a critical...

CONCLUSION: Perioperative nutritional optimization, including vitamin D repletion, vitamin C, magnesium support, MPFF therapy, and structured EAA supplementation, represents a safe, accessible, and evidence-supported strategy to enhance recovery after TJA. Integrating targeted nutrition into prehabilitation pathways may help reduce complications and support faster functional gains.

The integrity of the blood-retinal barrier remains largely unexplored in glaucoma. Here we show that elevated intraocular pressure partially compromises the blood-retinal barrier in three distinct mouse models of glaucoma. This compromise induces subtle leakage without bleeding or detectable disruption of endothelial cell junctions and precedes neurodegeneration. Leakage occurs from peripheral veins in the retinal ganglion cell layer with a concomitant loss of the transcytosis inhibitor MFSD2A....

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CONCLUSIONS: Single-tourniquet protocols yield synovial fluid amikacin concentrations in the TCJ and MTPJ similar to or higher than those of dual-tourniquet protocols, and wide rubber tourniquets result in more systemic leakage of amikacin compared to pneumatic tourniquets during saphenous IVRLP.