CONCLUSION: Automated SC morphometry reveals key age-dependent and sex-dependent differences in DCM. Age-based and sex-based morphometrics offer anatomically specific and individualized biomarkers for risk stratification, progression monitoring, and surgical outcome prediction.

CONCLUSION: Six weeks of CBT-I resulted in significant and sustained reductions in insomnia severity in older adults. Baseline sleep self-efficacy and depression severity significantly predicted lower insomnia severity following CBT-I, whereas only sleep self-efficacy predicted the long-term maintenance of treatment gains. These findings underscore the importance of baseline sleep self-efficacy as key predictor for optimizing treatment planning and long-term outcomes.

ADLumin is a new class of turn-on chemiluminescent probes that have shown increased luminescent intensity in the presence of amyloid beta ( A β $$ \mathrm{A}\beta $$ ) plaques, which are commonly associated with Alzheimer's disease (AD). ADLumin shares an imidazopyrazinone (IPO) moiety with the well-known Cypridina luciferin, which reacts with O(2) and produces bioluminescence. While the reaction mechanism for many other luciferins has been studied extensively, the chemiluminescent mechanism...

Phosphorylated peptides presented by human leukocyte antigen (HLA) class II molecules play pivotal roles in immune regulation, yet their characterization and prediction remain challenging due to data noise and limited HLA coverage. Here, we introduce NetMHCIIphosPan, a prediction method for HLA-II antigen presentation of phosphorylated peptides, developed using mass spectrometry (MS)-based immunopeptidomics data sets. Employing a refined peptide identification workflow, we reanalyzed earlier...

Porokeratoma (PRKT) is a rare epidermal acanthoma that can clinically resemble other hyperkeratotic or verrucous lesions, creating potential diagnostic uncertainty without histopathologic evaluation. It typically presents as a solitary exophytic lesion that lacks the annular architecture associated with other porokeratosis variants and may therefore be misclassified on clinical examination alone. We report the case of an immunocompetent 67-year-old male with a 10-week history of a progressively...