No abstract

The withdrawal of antibiotic growth promoters from poultry production has led to the resurgence of Clostridium perfringens-induced necrotic enteritis (NE), resulting in annual global economic losses exceeding $6 billion. With conventional antibiotics becoming less accessible for disease prevention, there is an urgent need for effective non-antibiotic alternatives. Bacteriophage therapy represents a promising approach, although its utility is often constrained by narrow host range and rapid...

CONCLUSIONS: Despite overall reductions in mortality, disparities by sex, race/ethnicity, and geography persist. The objective of this study was to explicitly assess long-term mortality trends and demographic disparities associated with DM and PAD in the United States, providing evidence to guide future preventive and policy measures. These results underscore the importance of targeted and equity-driven health interventions to reduce the burden of DM and PAD nationwide.

Metabolic alkalosis, characterized by an increase in serum bicarbonate (>28 mEq/L) and serum pH (>7.45), is associated with clinical complications including arrhythmias, mental confusion, and seizures. Non-pharmacologic measures are recommended first-line for treatment of hypochloremic metabolic alkalosis, but pharmacologic treatment may be needed. This review of the literature provides detailed descriptions of dosage regimens, efficacy, safety, and other considerations for use of pharmacologic...

CONCLUSIONS: STRIDE shows reproducible effectiveness and an acceptable safety profile in real-world practice. Achieving disease control and maintaining liver function emerged as key determinants of long-term survival benefit.