Physical activity (PA) is important for a woman's health particularly before pregnancy, yet many remain inactive during this time despite its benefits for themselves and their child. This qualitative descriptive study explored pregnant women's experiences with pre-pregnancy PA and the factors influencing their engagement. Using convenience sampling, data were collected from women across Nebraska between December 2023 and February 2024 via Zoom interviews. Thematic analysis, guided by the Theory...

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Biological aging disrupts liver-gut intercommunication, resulting in the development of insulin resistance and type 2 diabetes, coupled with the imbalance of gut microbiome composition known as gut dysbiosis. Fermented red ginseng (FRG) is a renowned functional food substance showing its notable anti-inflammatory and anti-diabetic effects owing to its unique bioactive compounds known as ginsenosides. However, whether FRG could impact biological aging and age-related metabolic dysfunction is...

Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation, synovial inflammation, osteophyte formation, joint space narrowing, and persistent pain. During OA progression, synovial inflammation triggers the release of pro-inflammatory cytokines, including IL-1β, TNF-α, and IL-6, which activate matrix metalloproteinases (MMPs) and aggrecanases, driving extracellular matrix (ECM) degradation. Emerging evidence indicates that transient receptor potential (TRP)...

CONCLUSIONS: TPI1 is a candidate functional biomarker of SHetA2 sensitivity in ovarian cancer.