High-fat diet (HFD) intake has been linked to an increased risk of pancreatic ductal adenocarcinoma (PDAC), a lethal and therapy-resistant cancer. However, whether and how specific dietary fats drive cancer development remains unresolved. Leveraging an oncogenic Kras-driven mouse model that closely mimics human PDAC progression, we screened a dozen isocaloric HFDs differing solely in fat source and representing the diversity of human fat consumption. Unexpectedly, diets rich in oleic acid - a...

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Virtual reality (VR) is increasingly being used as an innovative technology for assessment, treatment, and training within psychiatric settings. However, little work has been done to synthesize existing literature on the use and benefits of VR in forensic-correctional settings. This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline. Protocol is available at Open Science Framework (https://osf.io/3m6p2). A total of 1317...

This study explores the influence of experiencing one, two or more stressful life events (SLE) in the past year in associations with adolescent sleep and depression symptomatology in the short and long term in the context of coping. Participants were 2323 Hispanic (44.1%), non-Hispanic Black (30.5%), non-Hispanic White (8.6%), and non-Hispanic Asian (16.7%) eighth graders (51.1% female) from 24 public middle schools in southeast Texas in 2019. Multivariate linear and logistic regressions for the...

CONCLUSIONS: This formative pilot study will inform the cultural adaptation and refinement of an mHealth app, VITAL, which will be tested in a subsequent randomized controlled trial to improve health disparities and assist Hispanic people with HIV in quitting smoking.