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Aging is accompanied by progressive impairment of neurovascular coupling (NVC), the mechanism that matches local cerebral blood flow to neuronal activity, contributing to cognitive decline and the development of vascular cognitive impairment and dementia. Exposure to a young systemic milieu through heterochronic parabiosis has been shown to restore NVC in aged mice, suggesting that circulating factors can rejuvenate cerebrovascular function. Yet, the molecular mediators responsible for this...

Global heatwave intensification under climate change will impact the nitrogen cycle, yet its effect on active nitrifier groups or their interactions with viruses remains unclear. Using 13CO2-DNA-based stable-isotope probing coupled with metagenomics, we show that elevated temperatures under heatwave conditions fundamentally restructure active nitrifying communities and their associated viruses in Yangtze River estuary upper tidal flats and adjacent agricultural soils. In tidal flats, sustained...

The development of the hypothalamic-pituitary-adrenal (HPA) axis is sensitive to early life perturbations. We examined how an early-life perturbation, paternal deprivation, affects the HPA axis development of offspring and how maternal behavior is impacted by paternal deprivation. Using captive zebra finches, Taeniopygia guttata, we set up two paternal deprivation treatment groups in which we removed the father at hatching or at fledging. These two periods were chosen because they comprise two...

CONCLUSIONS: Cancer remains a major public health issue in the U.S. From 1990 to 2021, national cancer mortality and DALY rates decreased, but incidence increased, highlighting geographic, gender, and socioeconomic disparities. The focus should be on the top ten cancers contributing to DALYs, including ung, colorectal, breast, pancreatic, leukemia, prostate, non-Hodgkin lymphoma, brain, esophageal, and liver cancers, while addressing others as resources allow. Understanding shared etiologies is...